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Dosimetric and biological impact of activity extravasation of radiopharmaceuticals in PET imaging

Background: The increasing use of nuclear medicine and PET imaging has intensified scrutiny of radiotracer extravasation. To our knowledge, this topic is understudied but holds great potential for enhancing our understanding of extravasation in …

SIR-Spheres activity measurements reveal systematic miscalibration

Purpose: Accurate dosimetry-guided radiopharmaceutical therapy fundamentally relies on knowledge of the quantity of radioactivity administered to patients. The purpose of this work was to perform an independent and NIST-traceable activity measurement …

Monte Carlo evaluation of hypothetical long axial field-of-view PET scanner using GE Discovery MI PET front-end architecture

Purpose: The development of total-body PET scanners is of growing interest in the PET community. Investigation into the imaging properties of a hypothetical extended axial field-of-view (AFOV) GE Healthcare SiPM-based Discovery MI (DMI) system …

Half-Life of 67 Cu

The half life of 67Cu was determined through serial gamma ray spectrometry measurements of the dominant gamma emission produced following beta decay. Data were collected consecutively for 1000 s per measurement, with a total of 3063 measurements over …

Imaging and dosimetric characteristics of 67 Cu

In recent years the use of beta-emitting radiopharmaceuticals for cancer therapy has expanded rapidly following development of therapeutics for neuroendocrine tumors, prostate cancer, and other oncologic malignancies. One emerging beta-emitting …

Absorbed dose distributions from beta‐decaying radionuclides: Experimental validation of Monte Carlo tools for radiopharmaceutical dosimetry

The aim of this project is to experimentally validate the Monte Carlo generated absorbed doses from the beta particles emitted by 90Y and 177Lu using radiochromic EBT3 film‐based dosimetry. Line sources of 90Y and 177Lu were inserted longitudinally …

The Impact of Tissue Type and Density on Dose Point Kernels for Patient-Specific Voxel-Wise Dosimetry: A Monte Carlo Investigation

We report the generation of dose point kernels for clinically-relevant radionuclide beta decays and monoenergetic electrons in various tissues to understand the impact of tissue type on dose point kernels. Currently available voxel-wise dosimetry …

Reply to “Comment on ‘Observation of annual modulation induced by γ rays from (α,γ) reactions at the Soudan Underground Laboratory' ”

Annual modulation of γ rays from (α,γ) reactions induced by the α activity of radon and its daughters was reported by Tiwari, Zhang, Mei, and Cushman (TZMC). While Mohr does not contest the measurements themselves, he has commented that unrealistic …

Observation of annual modulation induced by γ rays from (α,γ) reactions at the Soudan Underground Laboratory

Annual modulation of γ rays from (α,γ) reactions in the Soudan Underground Laboratory was observed using a 12-liter scintillation detector. This significant annual modulation, measured over 4 years, can mimic the signature for dark matter and can …