High-resolution beta particles dosimetry using GATE Monte Carlo simulation for radiopharmaceutical dosimetry

Abstract

Patient-specific dosimetry is a very active field of research. For voxel-wise dosimetry, the dose point kernels method has recently gained considerable attention because of its potential to use image-based information for the calculation of absorbed dose in patient-specific targeted radionuclide therapy.

In this presentation, first I will present GATE simulation of the dose point kernels in phantoms of water, compact bone, lung, adipose, blood, and red marrow for radionuclides such as 177Lu, 90Y, 186Re, 188Re, 32P, 153Sm, and 89Sr and monoenergetic electrons (0.015-10) MeV. These new kernels provide the necessary inputs for next-generation voxel-wise dosimetry, which will account for tissue type and density.

In the second part, I will discuss about the high-resolution experimental validation of Monte Carlo-simulated 90Y and 177Lu beta particles dose deposition using a simple and innovative method. We have observed an excellent agreement between the GATE Monte Carlo simulation and experimental measurement.